factor v การใช้

• Factor V circulates as a single-chain procofactor which contains six domains, A1-A2-B-A3-C1-C2.
• Inactivation of Factor V a thus practically halts the production of thrombin.
• The best known and most common hereditary form is Factor V Leiden.
• "' Factor V Leiden thrombophilia "'is a genetic disorder of blood clotting.
• Like factor V Leiden, this abnormality is uncommon in Africans and Asians.
• One particular exosite augments protein C's ability to inactivate Factor V a efficiently.
• It is a variant of human factor V that causes a hypercoagulability disorder.
• The most common problem is the factor V Leiden and prothrombin G20210A mutation.
• Factor V Leiden increases the risk of venous thrombosis by two known mechanisms.
• Other mutations of factor V are associated with venous thrombosis.
• In people with thrombosis, 10 % have factor V Leiden.
• The factor V _ 0 is used for the normalization of the PSP kernels.
• Thrombin activates Factor V by cleaving off the B domain.
• Factor V is able to bind to activated platelets and is activated by thrombin.
• Factor Xa ( in the presence of factor V ) activates prothrombin into thrombin.
• Factor V Leiden is an inherited disorder of blood clotting.
• Platelet activation in turn degranulates and releases factor V and fibrinogen, potentiating the coagulation cascade.
• In Factor V Leiden, a G1691A nucleotide replacement results in an R506Q amino acid mutation.
• Overall, " factor V G1691A " mutation has been linked to the development of porencephaly.
• It acts by cleaving prothrombin in two places ( an co-factor V in the prothrombinase complex.